The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Abstract
Abstract Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity. This review highlights the diversity of the tetrodotoxin natural product family and discusses the origins of derivatives, biosynthetic hypotheses, and biological activities. Furthermore, potential therapeutic applications and structure–activity relationship studies are covered, along with the total syntheses of the natural product and selected derivatives that were published to date.
Article Details
Authors (7)
Benedikt Nißl
Department of Pharmacy Ludwig‐Maximilians‐Universität München Butenandtstr. 5–13, Haus C 81377 Munich Germany
Marcel Mülbaier
Drug Discovery Engine Grünenthal GmbH Zieglerstr. 6 52078 Aachen Germany
Francesca Grisoni
Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven AI Systems Institute 1 , Eindhoven,
Dirk Trauner
P. Roy and Diana T. Vagelos Laboratories, Department of Chemistry
Marcel Bermúdez
Clemens Dialer
Drug Discovery Engine Grünenthal GmbH Zieglerstr. 6 52078 Aachen Germany
David B. Konrad