The application of large language models in bariatric surgery: A scoping review

N Ningjing Guo X Xuyan Li X Xiaoxue Li C Congmin Kang X Xiaoyan Gong X Xinyu Ji J Jie Zheng (Key Laboratory of Radiation Physics and Technology, Ministry of Education, Institute of Nuclear Science and Technology)

Abstract

Background Exploratory applications of large language models within the specialized field of metabolic and bariatric surgery have begun to emerge. Nevertheless, existing research remains fragmented, lacking comprehensive integration. Objective To conduct a scoping review of studies on the application of large language models in the field of metabolic and bariatric surgery, aiming to provide a reference for clinical practice and future research. Methods This scoping review adhered to the Joanna Briggs Institute methodological framework and followed the preferred reporting items for systematic reviews and meta-Analyses extension for scoping reviews (PRISMA-ScR) guidelines.PubMed, Web of Science, The Cochrane Library, Embase, CINAHL, CNKI, Wanfang, and VIP databases were searched for relevant studies, with the search timeframe from database inception to November 2025. The included literature was summarized and analyzed. Results A total of 21 English-language studies were included. LLMs were primarily applied in scenarios such as patient education and information consultation, clinical decision support, and professional knowledge assessment. While LLMs performed well in information-provision tasks, they showed low consistency with expert opinions in complex clinical tasks such as individualized surgical recommendations. Performance varied across different models, with GPT-4 generally demonstrating superior performance, and domain-specific models showing professional potential. Current research still faces challenges regarding information accuracy, readability, and clinical applicability. Conclusion Large language models hold auxiliary potential in the field of metabolic and bariatric surgery, particularly for knowledge dissemination and patient education. However, their reliability in complex clinical decision-making remains limited. Future efforts should focus on conducting high-quality studies, advancing model specialization and standardized evaluation, and exploring safe and effective human-AI collaboration models.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 6
Published June 05, 2026
Pages e0350748
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (7)

N

Ningjing Guo

X

Xuyan Li

X

Xiaoxue Li

C

Congmin Kang

X

Xiaoyan Gong

X

Xinyu Ji

J

Jie Zheng

Key Laboratory of Radiation Physics and Technology, Ministry of Education, Institute of Nuclear Science and Technology