The antimetastatic effects of calorie restriction are negated by voluntary exercise in an aggressive breast cancer mouse model
Abstract
The role of lifestyle interventions in treatment success has become essential for nearly every disease. Healthy dietary habits, regular exercise, and stress management are key pillars that can improve quality of life during treatment, as well as delay disease onset and progression. In this study, we focus on the combination of mild calorie restriction (CR) and voluntary exercise as coadjuvants to chemotherapy in the treatment of triple-negative breast cancer using the 4T1 mouse model. In this model, voluntary exercise did not add benefits beyond chemotherapy plus CR in terms of primary tumor size, body composition, or physical performance, while dampening the antimetastatic effect of CR in the lungs of sedentary mice. These findings highlight the challenges of translating results from one preclinical model to another, and ultimately to humans. Diet and exercise type and chemotherapeutic agent influence the outcomes of each type of cancer. More research is needed to determine if and when exercise should be recommended to particular cancer patients.
Article Details
Journal Info
Proceedings of the National Academy of Sciences
National Academy of Sciences
Authors (17)
Amanda Garrido
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH
Eva Tamayo-Torres
Department of Physiology, Faculty of Pharmacy, University of Valencia
Sara Abdo
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Ethan Durham
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Jonathan Hirschenson
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Hikari Tanaka
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Eleonora Duregon
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Hazal Ozturk-Gurgen
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Mounisha Kovour
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Monica Bodogai
Immunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health
Arya Biragyn
Immunoregulation Section, Laboratory of Immunology and Molecular Biology, National Institute on Aging
Simonetta Camandola
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
Nathan L. Price
Translational Gerontology Branch, National Institute on Aging
Michel Bernier
Translational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH
Julián Carretero
Department of Physiology, Faculty of Pharmacy, University of Valencia
María Carmen Gómez-Cabrera
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana
Rafael de Cabo
Translational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH