The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes

W Wiktoria A. Pytel (Institute for Structural and Chemical Biology) U Urvashi Patel (Institute for Structural and Chemical Biology) J Joshua P. Smalley (Institute for Structural and Chemical Biology) C Christopher J. Millard (Institute for Structural and Chemical Biology) E Edward A. Brown (Institute for Structural and Chemical Biology) A Aline R. Pavan (School of Chemistry) S Siyu Wang J Jay H. Kalin (Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Department of Biological Chemistry and Molecular Pharmacology) J Jean Leandro dos Santos (São Paulo State University (UNESP)) P Philip A. Cole J James T. Hodgkinson (Institute for Structural and Chemical Biology) J John W. R. Schwabe (Institute for Structural and Chemical Biology)

Article Details

Volume / Issue Vol. 147, Issue 40
Published October 08, 2025
Pages 36044-36052
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

W

Wiktoria A. Pytel

Institute for Structural and Chemical Biology

U

Urvashi Patel

Institute for Structural and Chemical Biology

J

Joshua P. Smalley

Institute for Structural and Chemical Biology

C

Christopher J. Millard

Institute for Structural and Chemical Biology

E

Edward A. Brown

Institute for Structural and Chemical Biology

A

Aline R. Pavan

School of Chemistry

S

Siyu Wang

J

Jay H. Kalin

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Department of Biological Chemistry and Molecular Pharmacology

J

Jean Leandro dos Santos

São Paulo State University (UNESP)

P

Philip A. Cole

J

James T. Hodgkinson

Institute for Structural and Chemical Biology

J

John W. R. Schwabe

Institute for Structural and Chemical Biology