Targeting the NLRP3 inflammasome alleviates the comorbidity of chronic pain and depression via enhancing the autophagy

Peigen Zhang; Hongyan Liu; Jingjing Zhou; Shicong Wu; Cancan Song; Dongshan Zhao; Shuang Guo; Hui Gao; Haili Zhu

doi:10.1038/s41598-026-35400-0

Targeting the NLRP3 inflammasome alleviates the comorbidity of chronic pain and depression via enhancing the autophagy

P Peigen Zhang H Hongyan Liu (CAS Key Laboratory of Green Process and Engineering, State Key Laboratory of Multiphase Complex Systems, Beijing Key Laboratory of Ionic Liquids Clean Process, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China) J Jingjing Zhou S Shicong Wu C Cancan Song D Dongshan Zhao S Shuang Guo (Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University) H Hui Gao H Haili Zhu

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 16, Issue 1

Published January 09, 2026

DOI 10.1038/s41598-026-35400-0

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (9)

P

Peigen Zhang

H

Hongyan Liu

CAS Key Laboratory of Green Process and Engineering, State Key Laboratory of Multiphase Complex Systems, Beijing Key Laboratory of Ionic Liquids Clean Process, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

J

Jingjing Zhou

S

Shicong Wu

C

Cancan Song

D

Dongshan Zhao

S

Shuang Guo

Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University

H

Hui Gao

H

Haili Zhu

Targeting the NLRP3 inflammasome alleviates the comorbidity of chronic pain and depression via enhancing the autophagy

Article Details

Journal Info

Authors (9)

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