Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status

Y Yunyi Bian G Guangyao Shan G Guoshu Bi Z Zhijie Xu (Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory) J Jiaqi Liang (College of Chemistry, Beijing Normal University, No. 19, XinJieKouWai St, HaiDian District, Beijing 100875, P. R. China) Y Yuanliang Yan W Wei Guo Q Qihai Sui Y Yanjun Yi H Haochun Shi T Tao Lu H Huan Zhang (School of Agriculture and Biology) Q Qun Wang (State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research) H Hong Fan W Wei Jiang C Cheng Zhan