Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator

K Koon Mook Kang (Department of Chemistry) A Abigail L. Vargas (Department of Chemistry and Biochemistry) L Luana Assis Ferreira (Department of Psychological and Brain Sciences) B Benjamin James Des Soye (Department of Chemistry) M Mary Corrigan (Department of Chemistry and Biochemistry) C Cathy Kexin Zhang (Department of Chemistry) F Feng Wang D Dorothy Duan (Department of Chemistry) N Neil L. Kelleher (Department of Chemistry) A Andrea G. Hohmann (Department of Psychological and Brain Sciences) D Dali Liu (Department of Chemistry and Biochemistry) R Richard B. Silverman (Department of Chemistry)

Article Details

Volume / Issue Vol. 148, Issue 8
Published March 04, 2026
Pages 8736-8748
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

K

Koon Mook Kang

Department of Chemistry

A

Abigail L. Vargas

Department of Chemistry and Biochemistry

L

Luana Assis Ferreira

Department of Psychological and Brain Sciences

B

Benjamin James Des Soye

Department of Chemistry

M

Mary Corrigan

Department of Chemistry and Biochemistry

C

Cathy Kexin Zhang

Department of Chemistry

F

Feng Wang

D

Dorothy Duan

Department of Chemistry

N

Neil L. Kelleher

Department of Chemistry

A

Andrea G. Hohmann

Department of Psychological and Brain Sciences

D

Dali Liu

Department of Chemistry and Biochemistry

R

Richard B. Silverman

Department of Chemistry