Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC

G Guoshu Bi J Jiaqi Liang (College of Chemistry, Beijing Normal University, No. 19, XinJieKouWai St, HaiDian District, Beijing 100875, P. R. China) Y Yunyi Bian G Guangyao Shan S Shencheng Ren H Haochun Shi X Xiaolong Huang (Department of Chemistry and Biochemistry) J Junkan Zhu Q Qun Wang (State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research) W Wei Jiang B Boyi Gan C Cheng Zhan

Article Details

Volume / Issue Vol. 16, Issue 1
Published September 02, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (12)

G

Guoshu Bi

J

Jiaqi Liang

College of Chemistry, Beijing Normal University, No. 19, XinJieKouWai St, HaiDian District, Beijing 100875, P. R. China

Y

Yunyi Bian

G

Guangyao Shan

S

Shencheng Ren

H

Haochun Shi

X

Xiaolong Huang

Department of Chemistry and Biochemistry

J

Junkan Zhu

Q

Qun Wang

State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research

W

Wei Jiang

B

Boyi Gan

C

Cheng Zhan