Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

Davide Di Lorenzo; Nicolo Bisi; Julia Kaffy; Lisa Marie Ramirez; Markus Zweckstetter; Olivier Lequin; Irene Garfagnini; Jinghui Luo; Yvonne Hannappel; Inga Ennen; Veronica Dodero; Norbert Sewald; Maria Luisa Gelmi; Nicolo Tonali; Roland Brandt; Sandrine Ongeri

doi:10.1038/s41467-025-63824-1

Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

D Davide Di Lorenzo N Nicolo Bisi J Julia Kaffy L Lisa Marie Ramirez M Markus Zweckstetter O Olivier Lequin I Irene Garfagnini J Jinghui Luo (Center for Life Sciences, Paul Scherrer Institute, Villigen, 5232 Villigen, Switzerland) Y Yvonne Hannappel I Inga Ennen V Veronica Dodero N Norbert Sewald M Maria Luisa Gelmi N Nicolo Tonali R Roland Brandt S Sandrine Ongeri

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published October 01, 2025

DOI 10.1038/s41467-025-63824-1

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (16)

D

Davide Di Lorenzo

N

Nicolo Bisi

J

Julia Kaffy

L

Lisa Marie Ramirez

M

Markus Zweckstetter

O

Olivier Lequin

I

Irene Garfagnini

J

Jinghui Luo

Center for Life Sciences, Paul Scherrer Institute, Villigen, 5232 Villigen, Switzerland

Y

Yvonne Hannappel

I

Inga Ennen

V

Veronica Dodero

N

Norbert Sewald

M

Maria Luisa Gelmi

N

Nicolo Tonali

R

Roland Brandt

S

Sandrine Ongeri

Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

Article Details

Journal Info

Authors (16)

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