Sword and Board in One: A Bioinspired Nanocomposite Membrane for Guided Bone Regeneration
Abstract
Abstract Guided bone regeneration (GBR) faces far from a one‐dimensional challenge. It demands a multifunctional membrane to possess paradoxical but essential properties in sophisticated clinical scenarios. Drawing inspiration from natural biological structures and superior properties, through a combination of structure innovation and composition regulation, a multicomponent nacre‐inspired discontinuous Bouligand structure is devised and transcribed into a bioinspired Janus nanocomposite membrane with comprehensive properties for GBR, identical to “sword and board.” As a sword, our membrane can actively adapt to sharp bony ridges owing to high toughness, capture water molecules for fluid penetration, drive osteogenic expression, and kill bacteria. As a board, it can achieve superior mechanical strength to withstand external forces, passively maintain structural integrity for ingrowth barrier, while function as a passive substrate for cell adhesion and proliferation. Overall, the membrane with excellent mechanical properties and bio‐functions is the paradigm of the combinatorial design of component and structure. It achieves the contradictory yet prerequisite features in response to the current challenge and offers new hope to advance biomedical applications. Equally important, the fabrication of our multifunctional bioinspired membrane is mild, efficient, scalable, and thus is poised to inspire the design of a broader range of functional material systems.
Article Details
Authors (8)
Shuai Yuan
State Key Laboratory of Coordination Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering
Yanhuizhi Feng
Haicheng Wang
Si‐Ming Chen
Department of Chemistry Division of Nanomaterials & Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials & Chemistry Anhui Engineering Laboratory of Biomimetic Materials Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China
Jia‐Hao Li
Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS‐HKU Joint Laboratory on New Materials New Cornerstone Science Laboratory Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China
Yin‐Bo Zhu
Department of Modern Mechanics CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei 230027 China
Shu‐Hong Yu
New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials and Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China
Zuolin Wang