Substance P in the lateral hypothalamic area regulates binge‐like eating behaviors in mice
Abstract
Binge eating disorder (BED) is the most common type of eating disorder; however, the neural circuit mechanisms underlying BED remain elusive. Here, we report that tachykinin-expressing neurons in the lateral hypothalamic area (LH Tac1 neurons) are inhibited during binge-like eating behaviors in mice. We identified LH Tac1 neurons as key mediators of binge-like eating behaviors and reported that the LH Tac1 → lateral periaqueductal gray (LPAG) circuit is critical to the regulation of binge-like eating behaviors. Moreover, Substance P (SP) released by LH Tac1 neurons modulates binge-like eating behaviors by influencing the input of glutamate to LPAG cells, which receive projections from LH Tac1 neurons. In summary, these findings point to the SP as a key node in BED circuits.
Article Details
Journal Info
Proceedings of the National Academy of Sciences
National Academy of Sciences
Authors (10)
Xin-Yue Lv
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Qian-Qian Yang
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Yue Wang
Si-Ran Wang
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Jiu-Ye Qiao
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Shuang Liu
Frontiers Science Center for Transformative Molecules, State Key Laboratory of Polyolefins and Catalysis, School of Chemistry and Chemical Engineering
Hua-Li Yu
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Xiao-Xiao He
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Xiao-Juan Zhu
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University
Zi-Xuan He
Key Laboratory of Molecular Epigenetics Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University