Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites

A Aliki Perdikari V Virgil A. Woods A Ali Ebrahim K Katherine Lawler (Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.) R Rebecca Bounds D Dinesh S. Shah N Nathanael I. Singh T Tamar (Skaist) Mehlman B Blake T. Riley S Shivani Sharma J Jackson W. Morris J Julia M. Keogh E Elana Henning M Miriam Smith I I. Sadaf Farooqi (Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.) D Daniel A. Keedy

Article Details

Volume / Issue Vol. 301, Issue 12
Published December 01, 2025
Pages 110852
ISSN 0021-9258
Publisher Elsevier BV

Journal Info

Journal of Biological Chemistry

Elsevier BV

ISSN: 0021-9258 Open Access Life Sciences

Authors (16)

A

Aliki Perdikari

V

Virgil A. Woods

A

Ali Ebrahim

K

Katherine Lawler

Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.

R

Rebecca Bounds

D

Dinesh S. Shah

N

Nathanael I. Singh

T

Tamar (Skaist) Mehlman

B

Blake T. Riley

S

Shivani Sharma

J

Jackson W. Morris

J

Julia M. Keogh

E

Elana Henning

M

Miriam Smith

I

I. Sadaf Farooqi

Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.

D

Daniel A. Keedy