Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols

Hanako Murayama; Nathaniel Yakobov; Nassira Mahmoudi; Sasha Legrosdidier; Nicolas Fournier; Solène Zuttion; Kanata Matsumoto; Michihiro Nishimura; Jingwei Ji; Bruno Senger; Laurence Huck; Howard B. Gamper; Yoshiaki Kise; Ralph E. Kleiner; Mathieu Frechin; Ya-Ming Hou; Hubert D. Becker; Yuzuru Itoh; Frédéric Fischer; Osamu Nureki

doi:10.1038/s41467-026-73135-8

Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols

H Hanako Murayama N Nathaniel Yakobov N Nassira Mahmoudi S Sasha Legrosdidier N Nicolas Fournier S Solène Zuttion K Kanata Matsumoto M Michihiro Nishimura J Jingwei Ji B Bruno Senger L Laurence Huck H Howard B. Gamper Y Yoshiaki Kise R Ralph E. Kleiner M Mathieu Frechin Y Ya-Ming Hou H Hubert D. Becker Y Yuzuru Itoh F Frédéric Fischer O Osamu Nureki

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published May 28, 2026

DOI 10.1038/s41467-026-73135-8

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (20)

H

Hanako Murayama

N

Nathaniel Yakobov

N

Nassira Mahmoudi

S

Sasha Legrosdidier

N

Nicolas Fournier

S

Solène Zuttion

K

Kanata Matsumoto

M

Michihiro Nishimura

J

Jingwei Ji

B

Bruno Senger

L

Laurence Huck

H

Howard B. Gamper

Y

Yoshiaki Kise

R

Ralph E. Kleiner

M

Mathieu Frechin

Y

Ya-Ming Hou

H

Hubert D. Becker

Y

Yuzuru Itoh

F

Frédéric Fischer

O

Osamu Nureki

Structure of ergosteryl-aspartate synthase reveals how an entrapped tRNA is used like a prosthetic swinging arm in the synthesis of aminoacylated sterols

Article Details

Journal Info

Authors (20)

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