Structure-Guided Semisynthesis of Blasticidin S–Amicetin Chimeras as Selective Ribosome Inhibitors

C Cole Gannett (Department of Chemistry) K Kateland Tiller (Center for Emerging, Zoonotic, and Arthropod-borne Pathogens) S Somaia Abdelmegeed (Department of Biomedical Sciences and Pathobiology) M Micah Hoernig (Virginia Tech Center for Drug Discovery) A Ahmed A. Abouelkhair (Center for Emerging, Zoonotic, and Arthropod-borne Pathogens) M Mohamed N. Seleem (Center for Emerging, Zoonotic, and Arthropod-borne Pathogens) J James Weger-Lucarelli (Center for Emerging, Zoonotic, and Arthropod-borne Pathogens) A Anne M. Brown (Center for Emerging, Zoonotic, and Arthropod-borne Pathogens) A Andrew N. Lowell (Department of Chemistry)

Article Details

Volume / Issue Vol. 148, Issue 3
Published January 28, 2026
Pages 2963-2971
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

C

Cole Gannett

Department of Chemistry

K

Kateland Tiller

Center for Emerging, Zoonotic, and Arthropod-borne Pathogens

S

Somaia Abdelmegeed

Department of Biomedical Sciences and Pathobiology

M

Micah Hoernig

Virginia Tech Center for Drug Discovery

A

Ahmed A. Abouelkhair

Center for Emerging, Zoonotic, and Arthropod-borne Pathogens

M

Mohamed N. Seleem

Center for Emerging, Zoonotic, and Arthropod-borne Pathogens

J

James Weger-Lucarelli

Center for Emerging, Zoonotic, and Arthropod-borne Pathogens

A

Anne M. Brown

Center for Emerging, Zoonotic, and Arthropod-borne Pathogens

A

Andrew N. Lowell

Department of Chemistry