Structural Mimics of Hydrocarbon Intermediates Reveal Counterclockwise Cyclization Pathways in the Sesquiterpene Synthases TmS and NcECS

M Michael Groll H Heng Li P Philip Troycke (Center for Protein Assemblies, Department Bioscience, School of Natural Sciences, Technical University Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany) V Ville R. I. Kaila (Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, Stockholm 10691, Sweden) J Jeroen S. Dickschat (Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany)

Article Details

Volume / Issue Vol. 147, Issue 51
Published December 24, 2025
Pages 47742-47750
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (5)

M

Michael Groll

H

Heng Li

P

Philip Troycke

Center for Protein Assemblies, Department Bioscience, School of Natural Sciences, Technical University Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany

V

Ville R. I. Kaila

Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, Stockholm 10691, Sweden

J

Jeroen S. Dickschat

Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany