Structural Insights into Three Bifunctional Sesterterpene Synthases and Product Profile Investigation by Domain Swapping and Active Site Mutation

Z Zhenyu Lei (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China) R Ruiqing Lyu (State Key Laboratory of Natural and Biomimetic Drugs, Department of Biophysics, School of Basic Medical Sciences) W Wenlong Song (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China) C Chenyu Zhang L Lin Bai (State Key Laboratory of Natural and Biomimetic Drugs, Department of Biophysics, School of Basic Medical Sciences) D Donghui Yang M Ming Ma (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China)

Article Details

Volume / Issue Vol. 148, Issue 7
Published February 25, 2026
Pages 6981-6991
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

Z

Zhenyu Lei

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China

R

Ruiqing Lyu

State Key Laboratory of Natural and Biomimetic Drugs, Department of Biophysics, School of Basic Medical Sciences

W

Wenlong Song

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China

C

Chenyu Zhang

L

Lin Bai

State Key Laboratory of Natural and Biomimetic Drugs, Department of Biophysics, School of Basic Medical Sciences

D

Donghui Yang

M

Ming Ma

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China