Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the SARS-CoV-2 Proofreading Enzyme

J Junbo Wang (School of Physics and Information Technology) Y Yufan Pan (Department of Chemistry) Y Yixiao Liu (MOE Key Laboratory of Protein Science, School of Medicine) B Bo Huang G Ge Jin (MOE Key Laboratory of Protein Science, School of Medicine) L Lejin Zhang (Division of Life Sciences and Medicine) F Feng Zhou X Xiaoyu Chang (School of Pharmaceutical Sciences, State key laboratory of antiviral drugs) Y Yucen Huang (State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy) L Liming Yan (MOE Key Laboratory of Protein Science, School of Medicine) Y Yuanchen Dong (CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry) Z Zihe Rao D Dongsheng Liu (Department of Chemistry) Z Zhiyong Lou (MOE Key Laboratory of Protein Science, School of Medicine)

Article Details

Volume / Issue Vol. 147, Issue 25
Published June 25, 2025
Pages 21896-21906
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

J

Junbo Wang

School of Physics and Information Technology

Y

Yufan Pan

Department of Chemistry

Y

Yixiao Liu

MOE Key Laboratory of Protein Science, School of Medicine

B

Bo Huang

G

Ge Jin

MOE Key Laboratory of Protein Science, School of Medicine

L

Lejin Zhang

Division of Life Sciences and Medicine

F

Feng Zhou

X

Xiaoyu Chang

School of Pharmaceutical Sciences, State key laboratory of antiviral drugs

Y

Yucen Huang

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy

L

Liming Yan

MOE Key Laboratory of Protein Science, School of Medicine

Y

Yuanchen Dong

CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry

Z

Zihe Rao

D

Dongsheng Liu

Department of Chemistry

Z

Zhiyong Lou

MOE Key Laboratory of Protein Science, School of Medicine