Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5

R Rupam Biswas (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) A Ana Laura López-Serrano (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) A Apoorva Purohit (Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University) A Angelina Ramirez-Navarro (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) H Hsiang-Ling Huang (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) X Xiaolin Cheng S Sarah M. Heissler (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) I Isabelle Deschênes (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University) K Krishna Chinthalapudi (Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University)

Article Details

Volume / Issue Vol. 17, Issue 1
Published February 16, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (9)

R

Rupam Biswas

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

A

Ana Laura López-Serrano

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

A

Apoorva Purohit

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University

A

Angelina Ramirez-Navarro

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

H

Hsiang-Ling Huang

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

X

Xiaolin Cheng

S

Sarah M. Heissler

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

I

Isabelle Deschênes

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University

K

Krishna Chinthalapudi

Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University