STABILITY AND BIODISTRIBUTION STUDY OF TARAXACUM OFFICINALE NIOSOMES

Abstract

Recent progress in the study of such plants has resulted in isolation of about different phytoconstituents from plants. Among them 110 species of different plant families are mentioned their specific parts having protective action against certain liver disorder. Over the past several years, great advances have been made on development of novel drug delivery system (NDDS) for plant actives and extracts. The variety of novel herbal formulations like polymeric nanoparticles, microspheres, transferosomes and ethosomes has been reported using bioactive and plant extracts. The biodistribution pattern says that the dandelion loaded niosomes minimized the toxicity associated with plain dandelion solution. Vesicular systems not only help in targeting the drug the liver, but also help in providing controlled parenteral delivery by preventing metabolism of the drug from the enzymes present at the hepatic cells. Longer circulation of the niosomes showed that, incorporation of dandelion into the niosomes helped to increase the stability of dandelion by preventing it from chemical and enzymatic degradation. vesicles consisting of one or more surfactant bilayers enclosing aqueous spaces called niosomes have been considered of particular interest as they offer several advantages over liposomes with respect to chemical stability, lower cost and availability of materials. Lyophilized niosomal formulation (Proniosomes) were stable when stored at both refrigerated and room temperature.