Spatiotemporally controlled drug release via a click-release system utilizing mono-alkyl-hydroxylamine and cyclooctyne chemistry

X Xiaowei Xu X Xidan Tong (Center of Drug Discovery, State Key Laboratory of Natural Medicine) Y Yangfei Shi (Center of Drug Discovery, State Key Laboratory of Natural Medicine) X Xin Wang Y Yanzhao Chen (Center of Drug Discovery, State Key Laboratory of Natural Medicine) Y Yuanan Wang (Center of Drug Discovery, State Key Laboratory of Natural Medicine) M Mingxin Cheng S Shuanglong Chen H Hao Hao (State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics) Y Yan Liang (State Key Laboratory of Fine Chemicals, School of Chemistry) W Weiwei Guo (Center of Drug Discovery, State Key Laboratory of Natural Medicine) Y Yueqin Zheng (Center of Drug Discovery, State Key Laboratory of Natural Medicine)

Article Details

Volume / Issue Vol. 17, Issue 1
Published January 16, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (12)

X

Xiaowei Xu

X

Xidan Tong

Center of Drug Discovery, State Key Laboratory of Natural Medicine

Y

Yangfei Shi

Center of Drug Discovery, State Key Laboratory of Natural Medicine

X

Xin Wang

Y

Yanzhao Chen

Center of Drug Discovery, State Key Laboratory of Natural Medicine

Y

Yuanan Wang

Center of Drug Discovery, State Key Laboratory of Natural Medicine

M

Mingxin Cheng

S

Shuanglong Chen

H

Hao Hao

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics

Y

Yan Liang

State Key Laboratory of Fine Chemicals, School of Chemistry

W

Weiwei Guo

Center of Drug Discovery, State Key Laboratory of Natural Medicine

Y

Yueqin Zheng

Center of Drug Discovery, State Key Laboratory of Natural Medicine