Nature Communications

Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity

W Weida Qin (Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry) R Ruomeng Li (Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology) J Juan Liu J Jun Liu X Xiaoli Wang (Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.) B Binbin Hu (State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, and Department of Chemical Biology at School of Pharmaceutical Sciences) Z Zhen Zheng (School of Pharmacy) Z Zhilin Yu (Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China) G Gongyu Li (Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry)
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Article Details

Volume / Issue Vol. 16, Issue 1
Published July 25, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio
ISSN: 2041-1723 Open Access Life Sciences

Authors (9)

W

Weida Qin

Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry

R

Ruomeng Li

Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology

J

Juan Liu

J

Jun Liu

X

Xiaoli Wang

Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.

B

Binbin Hu

State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, and Department of Chemical Biology at School of Pharmaceutical Sciences

Z

Zhen Zheng

School of Pharmacy

Z

Zhilin Yu

Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China

G

Gongyu Li

Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry

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