SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis

P Pinglian Yang (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University) Z Zhechang Gao W Weile Ye (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University) C Chunhong Zhou (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University) Z Zhihua Zheng (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University) M Meiming Su Y Yu He (Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.) Z Zhuoming Li J Jaroslav Pelisek K Ke He (Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry) S Suowen Xu J Jiaojiao Wang (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University) Z Zhiping Liu (State Key Laboratory of Advanced Materials for Intelligent Sensing, Key Laboratory of Organic Integrated Circuit, Ministry of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, School of Science)

Article Details

Volume / Issue Vol. 17, Issue 1
Published April 15, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (13)

P

Pinglian Yang

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University

Z

Zhechang Gao

W

Weile Ye

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University

C

Chunhong Zhou

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University

Z

Zhihua Zheng

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University

M

Meiming Su

Y

Yu He

Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.

Z

Zhuoming Li

J

Jaroslav Pelisek

K

Ke He

Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry

S

Suowen Xu

J

Jiaojiao Wang

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education of China, College of Pharmacy, Jinan University

Z

Zhiping Liu

State Key Laboratory of Advanced Materials for Intelligent Sensing, Key Laboratory of Organic Integrated Circuit, Ministry of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Institute of Molecular Aggregation Science, School of Science