Size‐Selective Functionalization of Sugars and Polyols Using Zeolites for Renewable Surfactant Production

S Songlan Sun (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) Z Zezhong John Li (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) Y Yu‐Cheng Lin (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) M Manon Rolland (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) T Tom Nelis (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) S Seongmin Jin S Shasha Zheng (Leibniz−Institut Für Katalyse e.V. Rostock Germany) B Benjamin Nicolas Raffy (Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) W Wen Hua Bi E Esther Amstad (Soft Materials Laboratory Institution of Materials Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland) J Jeremy S. Luterbacher (Institute of Chemical Sciences and Engineering (ISIC))

Abstract

Abstract Diol functionalization with acetals in carbohydrates and polyols is ubiquitously used in protection chemistry and in the manufacture of several platform chemicals. However, the selective functionalization of molecules where multiple acetalization reactions can occur typically involves multiple protection/deprotection steps. Here, we show that zeolites can be used to size‐selectively acetalize sugars and polyols in a single step, and we demonstrate the potential of this approach for producing functional chemicals and materials. We show that high selectivity is dependent on effective pore confinement, which is achieved by a careful pairing of the substrate size and the zeolite morphology. This zeolite‐catalyzed strategy exhibited consistently good‐to‐excellent yields (70%–95%) of novel polyol/sugar monoacetals, notably offering an easy route to bio‐based amphiphiles. These resulting xylose‐based surfactants exhibited similar or superior surface activity and, remarkably, hard‐water resistance compared to their nonrenewable ethoxylated analogues, which illustrates the potential for practical applications of this approach.

Article Details

Volume / Issue Vol. 64, Issue 39
Published September 22, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (11)

S

Songlan Sun

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

Z

Zezhong John Li

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

Y

Yu‐Cheng Lin

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

M

Manon Rolland

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

T

Tom Nelis

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

S

Seongmin Jin

S

Shasha Zheng

Leibniz−Institut Für Katalyse e.V. Rostock Germany

B

Benjamin Nicolas Raffy

Laboratory of Sustainable and Catalytic Processing Institute of Chemicals Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

W

Wen Hua Bi

E

Esther Amstad

Soft Materials Laboratory Institution of Materials Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne CH‐1015 Switzerland

J

Jeremy S. Luterbacher

Institute of Chemical Sciences and Engineering (ISIC)