Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs

L Lei Huang (BLSA-ZJU Research Center and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China.) G Gang Qin C Chengcheng Gong Y Yajun Sun H Hui Yang C Cao Lv C Chong Liu (Department of Chemistry and Biochemistry) L Lu Jiang (School of Flexible Electronics (Future Technologies), Key Laboratory of Flexible Electronics, and Institute of Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China) J Jinduo Yuan M Mingyu Hu X Xinju Gao J Jun Yang X Xuesong Li Y Yu Si P Paul Song Y Yan Shi L Lili Shi B Bo Yang B Biyun Wang