Single‐Molecule Memristor Realizing Synaptic Plasticity for Neuromorphic Applications

L Li‐Yu‐Yang Shi (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) Y Yun‐Tao Ding (State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou P.R. China) X Xiao‐Di Liu (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) S Shun‐Da Wu (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) W Wen‐Jing Sun (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) B Bing Sun Y Yi‐Sheng Wei (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) Z Zheng Zhang S Shu‐Tong Liu (Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China) L Lichuan Chen (College of Materials & State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering & IKKEM) D Dong Xiang (Institute of Modern Optics, Center of Single-Molecule Sciences, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology) Y Yamin Zhang Z Zitong Liu (State Key Laboratory of Natural Product Chemistry, Key Laboratory of Special Function Materials and Structure Design (MOE), College of Chemistry and Chemical Engineering) H Hao‐Li Zhang (State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou P.R. China)

Abstract

ABSTRACT Neuromorphic computing, particularly memristor‐based architectures, offers a promising route to overcome the von Neumann bottleneck. Single‐molecule devices, with their high integration density and low energy consumption, represent an emerging platform for next‐generation computing. Here, we report the first optoelectronic volatile single‐molecule memristor based on the organic photovoltaic material Y6. The device exhibits reproducible conductance switching driven by electric‐field‐induced structural relaxation, enabling gradual and linear conductance modulation that mimics synaptic behavior. Under red‐light illumination, the Y6 junction shows a remarkable 457% increase in conductance and a significantly reduced switching threshold, demonstrating strong photoresponsivity and low‐power operation. Furthermore, frequency‐dependent pulse tests clearly reproduce short‐term synaptic plasticity (STP), demonstrating the memristor's ability to emulate dynamic synaptic functions. When the experimentally measured current response of the Y6 single‐molecule memristor is incorporated into an artificial neural network (ANN) model, the system achieves a speech‐recognition accuracy of 71.50%, closely matching that of the benchmark ANN (74.90%). This work pioneers the realization of synaptic functionality in a single‐molecule memristor and validates its application within an artificial neural network. It provides a new strategy for developing highly integrated molecular‐scale neuromorphic computing devices.

Article Details

Volume / Issue Vol. 1, Issue 1
Published June 23, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (14)

L

Li‐Yu‐Yang Shi

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

Y

Yun‐Tao Ding

State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou P.R. China

X

Xiao‐Di Liu

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

S

Shun‐Da Wu

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

W

Wen‐Jing Sun

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

B

Bing Sun

Y

Yi‐Sheng Wei

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

Z

Zheng Zhang

S

Shu‐Tong Liu

Department: State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Institution: Lanzhou University Address: Lanzhou University Lanzhou China

L

Lichuan Chen

College of Materials & State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering & IKKEM

D

Dong Xiang

Institute of Modern Optics, Center of Single-Molecule Sciences, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology

Y

Yamin Zhang

Z

Zitong Liu

State Key Laboratory of Natural Product Chemistry, Key Laboratory of Special Function Materials and Structure Design (MOE), College of Chemistry and Chemical Engineering

H

Hao‐Li Zhang

State Key Laboratory of Natural Product Chemistry Key Laboratory of Special Function Materials and Structure Design (MOE) College of Chemistry and Chemical Engineering Lanzhou University Lanzhou P.R. China