SHP2 in tumor-associated macrophages prompted the progression of colorectal cancer via modulating STAT3/PI3K signaling induced PD-1-mediated CAR-T cell apoptosis

Jianfa Xu; Jingbo Chen; Xiaoyu Zhang; Zibo Zhang; Guiying Wang

doi:10.1038/s41598-025-28261-6

SHP2 in tumor-associated macrophages prompted the progression of colorectal cancer via modulating STAT3/PI3K signaling induced PD-1-mediated CAR-T cell apoptosis

J Jianfa Xu J Jingbo Chen X Xiaoyu Zhang Z Zibo Zhang (Electrical Engineering Division, Department of Engineering, University of Cambridge) G Guiying Wang

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 15, Issue 1

Published December 29, 2025

DOI 10.1038/s41598-025-28261-6

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (5)

J

Jianfa Xu

J

Jingbo Chen

X

Xiaoyu Zhang

Z

Zibo Zhang

Electrical Engineering Division, Department of Engineering, University of Cambridge

G

Guiying Wang

SHP2 in tumor-associated macrophages prompted the progression of colorectal cancer via modulating STAT3/PI3K signaling induced PD-1-mediated CAR-T cell apoptosis

Article Details

Journal Info

Authors (5)

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