Sensitive and Accurate Detection of Low-frequency Mutations via Pyrophosphorolysis-Activated Selective Amplification and MALDI-TOF-MS Single-Nucleotide Resolution Identification

S Shanshan Liang (Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research) Y Yu Ning (Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research) X Xiaoting Wu G Guihua Zhang (Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research) Y Yinuo Hou (Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research) R Rui Wang X Xing Xu C Chaoyong Yang (State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, School of Life Sciences, Faculty of Medicine and Life Sciences)

Article Details

Volume / Issue Vol. 147, Issue 40
Published October 08, 2025
Pages 36223-36232
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

S

Shanshan Liang

Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research

Y

Yu Ning

Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research

X

Xiaoting Wu

G

Guihua Zhang

Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research

Y

Yinuo Hou

Collaborative Innovation Center of Chemistry for Energy Materials, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research

R

Rui Wang

X

Xing Xu

C

Chaoyong Yang

State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, School of Life Sciences, Faculty of Medicine and Life Sciences