Self-Splicing RNA Platform Encodes Twin PROTACs for Dual-E3 Ligase Recruitment and Programmable Protein Degradation

J Jiani Ding S Shumin Wang (Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering) Z Zijie Tang (Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering) Y Yao Li P Peisen Zhang (Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering) Z Zhi-Ling Song (Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering) X Xiliang Luo (Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering) X Xiao-Bing Zhang (State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering)

Article Details

Volume / Issue Vol. 1, Issue 1
Published July 22, 2026
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

J

Jiani Ding

S

Shumin Wang

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering

Z

Zijie Tang

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering

Y

Yao Li

P

Peisen Zhang

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering

Z

Zhi-Ling Song

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering

X

Xiliang Luo

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, College of Chemistry and Molecular Engineering

X

Xiao-Bing Zhang

State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering