SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

Abstract

Self- nano emulsifying drug delivery system (SNEDDS) is getting popularity for enhancing the solubility of hydrophobic drugs. SNEDDS are employed to solve issues regarding low bioavailability of poorly soluble and greatly permeable compounds. The SNEDDS are isotropic mixtures of solvents, co-solvents, surfactants and oil. The chief characteristic of SNEDDS is their capability to make acceptable Microemulsions or oil‐in‐water (o/w) emulsions with mild agitation. SNEDDS comprise a less content of lipid whereas greater amount of lipophobic surfactants and co-surfactants. Usually SNEDDS prepared as liquid, but several methods have been developed for converting liquid SNEEDS into solid forms, extrusion, and melting, spray-drying, adsorption onto porous carriers freeze drying. Due to vast development of this technology, SNEDDS will assist novel applications in drug delivery and resolve difficulties related with the poorly soluble drug delivery.