Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice

FuGuo Liu; Mubin Tarannum; Yingjie Zhao; Yiming J. Zhang; James Dongjoo Ham; Kewen Lei; Yuhao Qiang; Xingyu Deng; Maily Nguyen; Khanhlinh Dinh; Shaobo Yang; Alaa Kassim Ali; Toni K. Choueiri; Jerome Ritz; Rizwan Romee; Jianzhu Chen

doi:10.1038/s41467-025-63863-8

Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice

F FuGuo Liu M Mubin Tarannum Y Yingjie Zhao (College of Chemistry and Pingyuan Laboratory) Y Yiming J. Zhang J James Dongjoo Ham K Kewen Lei Y Yuhao Qiang X Xingyu Deng M Maily Nguyen K Khanhlinh Dinh S Shaobo Yang A Alaa Kassim Ali T Toni K. Choueiri (Department of Medical Oncology Dana‐Farber Cancer Institute Boston Massachusetts USA) J Jerome Ritz (Dana–Farber Cancer Institute, Boston) R Rizwan Romee J Jianzhu Chen

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published October 08, 2025

DOI 10.1038/s41467-025-63863-8

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (16)

F

FuGuo Liu

M

Mubin Tarannum

Y

Yingjie Zhao

College of Chemistry and Pingyuan Laboratory

Y

Yiming J. Zhang

J

James Dongjoo Ham

K

Kewen Lei

Y

Yuhao Qiang

X

Xingyu Deng

M

Maily Nguyen

K

Khanhlinh Dinh

S

Shaobo Yang

A

Alaa Kassim Ali

T

Toni K. Choueiri

Department of Medical Oncology Dana‐Farber Cancer Institute Boston Massachusetts USA

J

Jerome Ritz

Dana–Farber Cancer Institute, Boston

R

Rizwan Romee

J

Jianzhu Chen

Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice

Article Details

Journal Info

Authors (16)

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