Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates

Fei Wang; Victor Banerjee; Carla Barria; Santiago Ramirez; Tyler Allison; Damian Gorski; Haley Evans; Quynh Nguyen; Danielle Harrison; Rabab Al-Lahham; Nicole De Gregorio Carbonell; Michelle Pinho; Sanne Kaalund; Jonas Folke; Susana Aznar; Luis Concha-Marambio; Mohd Ishtikhar; Venkata KPS Mallampalli; Sandra Pritzkow; Mohammad Shahnawaz; Matthew L. Baker; Irina Serysheva; Claudio Soto

doi:10.1038/s41467-025-66146-4

Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates

F Fei Wang V Victor Banerjee C Carla Barria S Santiago Ramirez T Tyler Allison D Damian Gorski H Haley Evans Q Quynh Nguyen D Danielle Harrison R Rabab Al-Lahham N Nicole De Gregorio Carbonell M Michelle Pinho S Sanne Kaalund J Jonas Folke S Susana Aznar L Luis Concha-Marambio M Mohd Ishtikhar V Venkata KPS Mallampalli S Sandra Pritzkow M Mohammad Shahnawaz M Matthew L. Baker I Irina Serysheva C Claudio Soto

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published December 10, 2025

DOI 10.1038/s41467-025-66146-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (23)

F

Fei Wang

V

Victor Banerjee

C

Carla Barria

S

Santiago Ramirez

T

Tyler Allison

D

Damian Gorski

H

Haley Evans

Q

Quynh Nguyen

D

Danielle Harrison

R

Rabab Al-Lahham

N

Nicole De Gregorio Carbonell

M

Michelle Pinho

S

Sanne Kaalund

J

Jonas Folke

S

Susana Aznar

L

Luis Concha-Marambio

M

Mohd Ishtikhar

V

Venkata KPS Mallampalli

S

Sandra Pritzkow

M

Mohammad Shahnawaz

M

Matthew L. Baker

I

Irina Serysheva

C

Claudio Soto

Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates

Article Details

Journal Info

Authors (23)

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