SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation

Mengxin Luo

Jun Mo

Ziqiao Wang

Huimin Wei

Kexin Chen

Liteng Shen

Ying Wang

Linjie Li

Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Yongkang Chen

State Key Laboratory of Coordination Chemistry, MOE Key Laboratory of Mesoscopic Chemistry, MOE Key Laboratory of High Performance Polymer Materials and Technology, Jiangsu Key Laboratory of Advanced Organic Materials, Suzhou Key Laboratory of Green Intelligent Manufacturing of New Energy Materials and Devices, Tianchang New Materials and Energy Technology Research Center, Institute of Green Chemistry and Engineering, School of Sustainable Energy and Resources, School of Chemistry and Chemical Engineering

Weihao Chen

Xue Li

Hui Feng

Engineering Research Center for Nanophotonics & Advanced Instrument (Ministry of Education), Shanghai Key Laboratory of Magnetic Resonance, Institute of Magnetic Resonance and Molecular Imaging in Medicine, School of Physics

Xinyu Wang

Huan Zhou

Bizhi Li

Feng Xu

Faculty of Pharmaceutical Sciences

Qingwei Zhao

Yichen Xu

Jinxin Che

College of Pharmaceutical Sciences

Peng Zou

College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Peking University

Rong Zhang

Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, China

Xiaowu Dong

College of Pharmaceutical Sciences

Wei Xie