Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles

K Kah Yong Goh (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) W Wen Xing Lee (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) Q Qian Gou (Department of Chemistry, School of Chemistry and Chemical Engineering, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, P. R. China) S Sze Mun Choy (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) S Shi Chee Ong (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) P Priya D. Gopal Krishnan (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) H Huaxin Wang L Lewin Raymarc Roldan Turqueza Q Qian Hui Tan K Kenon Chua (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School) S Shang Li J Jun Nishiyama N Nathan Harmston (Molecular Biosciences Division, Cardiff School of Biosciences, Cardiff University) H Hong-Wen Tang (Program in Cancer and Stem Cell Biology, Duke-NUS Medical School)

Article Details

Volume / Issue Vol. 17, Issue 1
Published April 27, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (14)

K

Kah Yong Goh

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

W

Wen Xing Lee

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

Q

Qian Gou

Department of Chemistry, School of Chemistry and Chemical Engineering, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, P. R. China

S

Sze Mun Choy

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

S

Shi Chee Ong

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

P

Priya D. Gopal Krishnan

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

H

Huaxin Wang

L

Lewin Raymarc Roldan Turqueza

Q

Qian Hui Tan

K

Kenon Chua

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School

S

Shang Li

J

Jun Nishiyama

N

Nathan Harmston

Molecular Biosciences Division, Cardiff School of Biosciences, Cardiff University

H

Hong-Wen Tang

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School