Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1 study

François Rannou; Lucille Desallais; Christelle Nguyen; Camille Daste; Quentin Kirren; Marie-Martine Lefevre-Colau; Odile Launay; Hadley Mouhsine; Barbara Ruiz; Gabriel Moreau; Florent Langenfeld; Edita Dolimier; Hervé Do; René Azoulai; Francis Berenbaum; Marie-Christophe Boissier; Jean-Pierre Salles; Jean-François Zagury

doi:10.1038/s41467-025-64710-6

Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1 study

F François Rannou L Lucille Desallais C Christelle Nguyen C Camille Daste Q Quentin Kirren M Marie-Martine Lefevre-Colau O Odile Launay H Hadley Mouhsine B Barbara Ruiz G Gabriel Moreau F Florent Langenfeld E Edita Dolimier H Hervé Do R René Azoulai F Francis Berenbaum M Marie-Christophe Boissier J Jean-Pierre Salles J Jean-François Zagury

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published November 05, 2025

DOI 10.1038/s41467-025-64710-6

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (18)

F

François Rannou

L

Lucille Desallais

C

Christelle Nguyen

C

Camille Daste

Q

Quentin Kirren

M

Marie-Martine Lefevre-Colau

O

Odile Launay

H

Hadley Mouhsine

B

Barbara Ruiz

G

Gabriel Moreau

F

Florent Langenfeld

E

Edita Dolimier

H

Hervé Do

R

René Azoulai

F

Francis Berenbaum

M

Marie-Christophe Boissier

J

Jean-Pierre Salles

J

Jean-François Zagury

Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1 study

Article Details

Journal Info

Authors (18)

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