Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

Emilia Sinderewicz; Maria Dąbkowska; Anna Sarnowska; Joanna Staszkiewicz-Chodor; Dorota Mystkowska; Piotr Holak; Igor Drozd; Magdalena Chodkowska-Michalowska; Monika Rytel; Edyta Paczkowska; Marcin P. Mycko; Boguslaw Machalinski; Katarzyna Jezierska-Wozniak

doi:10.1038/s41598-026-40196-0

Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

E Emilia Sinderewicz M Maria Dąbkowska A Anna Sarnowska J Joanna Staszkiewicz-Chodor D Dorota Mystkowska P Piotr Holak I Igor Drozd M Magdalena Chodkowska-Michalowska M Monika Rytel E Edyta Paczkowska M Marcin P. Mycko B Boguslaw Machalinski K Katarzyna Jezierska-Wozniak

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Article Details

Journal Scientific Reports

Volume / Issue Vol. 16, Issue 1

Published February 27, 2026

DOI 10.1038/s41598-026-40196-0

ISSN 2045-2322

Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (13)

E

Emilia Sinderewicz

M

Maria Dąbkowska

A

Anna Sarnowska

J

Joanna Staszkiewicz-Chodor

D

Dorota Mystkowska

P

Piotr Holak

I

Igor Drozd

M

Magdalena Chodkowska-Michalowska

M

Monika Rytel

E

Edyta Paczkowska

M

Marcin P. Mycko

B

Boguslaw Machalinski

K

Katarzyna Jezierska-Wozniak

Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

Article Details

Journal Info

Authors (13)

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