Sacituzumab Tirumotecan in EGFR-TKI–Resistant, <i>EGFR</i> -Mutated Advanced NSCLC

W Wenfeng Fang (Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China) L Lin Wu (The Department of Thoracic Medical Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China) X Xiangjiao Meng (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China) Y Yu Yao (Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering) W Wei Zuo (Department of Respiratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang, China) W Wenxiu Yao (Department of Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China) Y Yanyan Xie (Department of Breast Surgical Oncology, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China) Y Yu Zhang (Xiangya Hospital, Central South University Changsha China) J Jiuwei Cui Y Yongchang Zhang X Xingya Li (Department of Medical Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China) W Wu Zhuang (Department of Thoracic Oncology, Fujian Cancer Hospital, Fuzhou, China) J Jian Fang Q Qiming Wang (Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Institute of Cancer Research, Henan Academy of Innovations in Medical Science, Zhengzhou, China) W Wei Jiang K Kai Li Y Yuju Bai (Department of Thoracic Oncology, Second Affiliated Hospital of Zunyi Medical University, Zunyi, China) Y Yongzhong Luo (Thoracic Medicine Department I, Hunan Cancer Hospital/Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China) F Fang Ma Y Yan Yu (Department of Respiratory Oncology Harbin Medical University Cancer Hospital Harbin China) W Wei Zheng Z Zhentian Liu (Department of Thoracic Oncology, Jiangxi Cancer Hospital, Nanchang, China) B Bin Yang R Rui Ma (College of Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, College of Energy, School of Life Sciences, College of Physical Science and Technology, and Discipline of Intelligent Instrument and Equipment) Y Yong Fang R Runxiang Yang (Department of Internal Medicine I, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China) L Liyan Jiang (Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai) J Jie Hu (School of Biomedical Sciences and Engineering) J Jiacheng Yang (Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China) Y Yina Diao (Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China) X Xiaoping Jin (Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China) J Junyou Ge (National Engineering Research Center of Targeted Biologics, Chengdu, China) Y Yunpeng Yang (Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China) L Li Zhang

Article Details

Volume / Issue Vol. 394, Issue 1
Published January 01, 2026
Pages 13-26
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (34)

W

Wenfeng Fang

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China

L

Lin Wu

The Department of Thoracic Medical Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China

X

Xiangjiao Meng

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China

Y

Yu Yao

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering

W

Wei Zuo

Department of Respiratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang, China

W

Wenxiu Yao

Department of Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China

Y

Yanyan Xie

Department of Breast Surgical Oncology, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

Y

Yu Zhang

Xiangya Hospital, Central South University Changsha China

J

Jiuwei Cui

Y

Yongchang Zhang

X

Xingya Li

Department of Medical Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

W

Wu Zhuang

Department of Thoracic Oncology, Fujian Cancer Hospital, Fuzhou, China

J

Jian Fang

Q

Qiming Wang

Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Institute of Cancer Research, Henan Academy of Innovations in Medical Science, Zhengzhou, China

W

Wei Jiang

K

Kai Li

Y

Yuju Bai

Department of Thoracic Oncology, Second Affiliated Hospital of Zunyi Medical University, Zunyi, China

Y

Yongzhong Luo

Thoracic Medicine Department I, Hunan Cancer Hospital/Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China

F

Fang Ma

Y

Yan Yu

Department of Respiratory Oncology Harbin Medical University Cancer Hospital Harbin China

W

Wei Zheng

Z

Zhentian Liu

Department of Thoracic Oncology, Jiangxi Cancer Hospital, Nanchang, China

B

Bin Yang

R

Rui Ma

College of Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, College of Energy, School of Life Sciences, College of Physical Science and Technology, and Discipline of Intelligent Instrument and Equipment

Y

Yong Fang

R

Runxiang Yang

Department of Internal Medicine I, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China

L

Liyan Jiang

Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai

J

Jie Hu

School of Biomedical Sciences and Engineering

J

Jiacheng Yang

Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China

Y

Yina Diao

Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China

X

Xiaoping Jin

Clinical Research Center, Sichuan Kelun-Biotech Biopharmaceutical, Chengdu, China

J

Junyou Ge

National Engineering Research Center of Targeted Biologics, Chengdu, China

Y

Yunpeng Yang

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China

L

Li Zhang