Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

L Liyan Zhang Y Yun Chen S Sylvestre Bonnet (Leiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands)

Abstract

Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years, this tunability has enabled precise control over their interactions with peptides and proteins, opening new avenues in therapeutic and analytical applications. This minireview provides a concise overview of the growing role of ruthenium complexes in protein science, with a focus on latest advances in protein targeting, inhibition, labelling, and sensing.

Article Details

Volume / Issue Vol. 65, Issue 4
Published January 22, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (3)

L

Liyan Zhang

Y

Yun Chen

S

Sylvestre Bonnet

Leiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands