Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules

M Michael J. Bond (Department of Pediatric Oncology, Dana-Farber Cancer Institute) R Ryan P. Golden (Department of Chemistry) G Giulia DiGiovanni (Department of Pediatric Oncology, Dana-Farber Cancer Institute) B Briana Howard (Department of Pediatric Oncology, Dana-Farber Cancer Institute) R Roman C. Sarott (Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H) B Basel A. Karim (Department of Chemistry) S Sai Gourisankar G Gabriela Alexe (Department of Pediatric Oncology, Dana-Farber Cancer Institute) K Kenneth Ross (Department of Pediatric Oncology, Dana-Farber Cancer Institute) H Hannah M. Jones (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) B Brendan G. Dwyer (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) N Nathanael S. Gray K Kimberly Stegmaier (Department of Pediatric Oncology, Dana-Farber Cancer Institute)

Article Details

Volume / Issue Vol. 147, Issue 49
Published December 10, 2025
Pages 44739-44758
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (13)

M

Michael J. Bond

Department of Pediatric Oncology, Dana-Farber Cancer Institute

R

Ryan P. Golden

Department of Chemistry

G

Giulia DiGiovanni

Department of Pediatric Oncology, Dana-Farber Cancer Institute

B

Briana Howard

Department of Pediatric Oncology, Dana-Farber Cancer Institute

R

Roman C. Sarott

Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H

B

Basel A. Karim

Department of Chemistry

S

Sai Gourisankar

G

Gabriela Alexe

Department of Pediatric Oncology, Dana-Farber Cancer Institute

K

Kenneth Ross

Department of Pediatric Oncology, Dana-Farber Cancer Institute

H

Hannah M. Jones

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

B

Brendan G. Dwyer

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

N

Nathanael S. Gray

K

Kimberly Stegmaier

Department of Pediatric Oncology, Dana-Farber Cancer Institute