Responsive Ordered Assembly of Magnetic Nanoparticles for ROS Activatable Magnetic Particle Imaging
Abstract
Abstract Magnetic particle imaging (MPI) has emerged as a versatile biomedical imaging modality, yet a significant challenge persists in the absence of activatable MPI probes for targeted imaging of disease biomarkers. In this study, a reactive oxygen species (ROS)‐responsive ordered assembly of magnetic nanoparticles (MNPs) is reported, engineered through the meticulous design of magnetic nanoparticle building blocks and ROS‐responsive polymeric ligands, enabling precise control over the assembly structure. This ordered configuration amplifies magnetic dipole‐dipole interactions, raising the energy barrier during nonequilibrium dynamic magnetization and effectively quenching the MPI signal. By modulating the assembly and disassembly of these ordered structures in response to ROS, this nanoprobe achieves ROS‐dependent off/on MPI signal regulation. Consequently, the probe enables the monitoring of early pathological ROS change in a mice model of early acute liver injury, facilitating highly sensitive monitoring of the ROS level‐dependent severity of the disease. This work represents the inaugural application of microenvironment‐responsive MPI probes for the early diagnosis of ROS‐associated diseases. The introduction of ordered assembly structures for MPI signal tuning offers a promising translational approach in the development of next‐generation activatable MPI probes.
Article Details
Authors (12)
Canyu Huang
Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering School of Biomedical Engineering National Center for Translational Medicine National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy Shanghai Jiao Tong University Shanghai 200240 P.R. China
Qilong Li
Qiyue Wang
Yang Du
Bo Zhang
Bingzhe Wang
Jinan University , , , ,
Zeyu Liang
State Key Laboratory of Synergistic Chem-Bio Synthesis, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), National Center for Translational Medicine
Guangyuan Shi
CAS Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences Beijing 100190 P. R. China
Jielin Sun
Jie Tian
Fangyuan Li
Department of Clinical Laboratory, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders
Daishun Ling
State Key Laboratory of Synergistic Chem-Bio Synthesis, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), National Center for Translational Medicine