Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy

Xueshui Guo; Ravindra Singh Prajapati; Jiyeon Chun; Insuk Byun; Kamil K. Gebis; Yi-Zhi Wang; Karen Ling; Casey Dalton; Jeff A. Blair; Anahid Hamidianjahromi; Gemma Bachmann; Frank Rigo; Paymaan Jafar-nejad; Jeffrey N. Savas; Min Jae Lee; Jemeen Sreedharan; Robert G. Kalb

doi:10.1038/s41467-025-65104-4

Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy

X Xueshui Guo R Ravindra Singh Prajapati J Jiyeon Chun I Insuk Byun K Kamil K. Gebis Y Yi-Zhi Wang K Karen Ling C Casey Dalton J Jeff A. Blair A Anahid Hamidianjahromi G Gemma Bachmann F Frank Rigo P Paymaan Jafar-nejad J Jeffrey N. Savas (Department of Neurology, Feinberg School of Medicine, Northwestern University) M Min Jae Lee (Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine) J Jemeen Sreedharan R Robert G. Kalb

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 16, 2026

DOI 10.1038/s41467-025-65104-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (17)

X

Xueshui Guo

R

Ravindra Singh Prajapati

J

Jiyeon Chun

I

Insuk Byun

K

Kamil K. Gebis

Y

Yi-Zhi Wang

K

Karen Ling

C

Casey Dalton

J

Jeff A. Blair

A

Anahid Hamidianjahromi

G

Gemma Bachmann

F

Frank Rigo

P

Paymaan Jafar-nejad

J

Jeffrey N. Savas

Department of Neurology, Feinberg School of Medicine, Northwestern University

M

Min Jae Lee

Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine

J

Jemeen Sreedharan

R

Robert G. Kalb

Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy

Article Details

Journal Info

Authors (17)

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