RECENT DEVELOPMENTS IN QUERCETIN-LOADED NANOPARTICLES FOR CANCER TARGETING

Abstract

Quercetin, a dietary polyphenol, has demonstrated anticancer properties across several malignancies, including pancreatic cancer, breast cancer, and melanoma. Quercetin is a naturally occurring bioflavonoid found in fruits, vegetables, seeds, berries, and tea. The cancer-preventive properties of quercetin are well established, attributed to its anti-inflammatory, anti-proliferative, and anti-angiogenic effects. Nonetheless, the inadequate water solubility and transport, chemical instability, brief half-life, and low bioavailability of quercetin restrict its therapeutic use in cancer chemoprevention. A comprehensive understanding of the molecular mechanisms governing controlled and regulated drug delivery is crucial for developing innovative and effective therapeutics. To surmount the accessibility constraints of quercetin, it may be administered as nano-conjugated quercetin. Nano-conjugated quercetin has garnered significant interest owing to its regulated drug release, prolonged retention in tumors, improved anticancer efficacy, and potential for therapeutic application. This paper presents an overview of quercetin's effects on cancer cells and the mechanisms behind these actions. We also examine the prospective usage of nanoparticles as nanocarriers in medicine delivery systems. This review can summarize the recent developments in quercetin-loaded Nanoparticles for Cancer treatment.