Radical Ring Expansion Catalyzed by an α-Ketoglutarate-Dependent Dioxygenase in the Biosynthesis of Tropolones

M Mingjie Liu (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology) J Jiawang Liu (Frontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering) S Songlin Bai (National Institute of Biological Sciences) Z Ziang Chen (State Key Laboratory of Bioactive Substance and Function of Natural Medicines) Y Yaling Wu (Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital) D Dan Du (Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital) X Xiangbing Qi (National Institute of Biological Sciences) X Xiaojing He (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology) Y Youcai Hu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines)

Article Details

Volume / Issue Vol. 147, Issue 35
Published September 03, 2025
Pages 32167-32177
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

M

Mingjie Liu

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology

J

Jiawang Liu

Frontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering

S

Songlin Bai

National Institute of Biological Sciences

Z

Ziang Chen

State Key Laboratory of Bioactive Substance and Function of Natural Medicines

Y

Yaling Wu

Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital

D

Dan Du

Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital

X

Xiangbing Qi

National Institute of Biological Sciences

X

Xiaojing He

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology

Y

Youcai Hu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines