Racial and ethnic disparities in neuroblastoma incidence and mortality: A systematic review and meta-analysis.

Abstract

e22008 Background: Neuroblastoma is the solid extracranial tumor most common in the infancy, with a high mortality. Studies shows racial/ethnic disparities in the outcomes, with black and hispanic children showing higher risk and worst prognosis compared to the white children Methods: Scopus, PubMed and Web of Science databases were systematically searched for studies that presented data about racial/ethnic disparity in neuroblastoma incidence and mortality. The outcomes assessed were racial/ethnic incidence, survival overall, mortality, and risk of death. Statistical analysis as performed using RStudio 4.3.1. Heterogeneity was assessed with I2 statistics, and a random-risk effect was used if I2 > 25%. Results: 3 case-control, 4 retrospective cohort, 6 Descriptive Retrospective Observational studies were included with 26.248 patients with neuroblastoma. Mean age were children 0 to 19 years old and 5 to 10 years of follow up. On incidence of neuroblastoma, there are results on incidence on Hispanic versus White (OR=0.5284; 95% IC 0.4931; 0.5661;P<0.001); incidence on Asian/Pacifc Islander versus White (OR=0.5895; 95% IC 0.5202;0.6680; P<0.001);incidence on American Indian/ Alaska Native versus White (OR=0.4469; 95% IC 0.1778;1.1232; P=0.087); incidence on Black versus White (OR=0.8391; 95% IC 0.6709; 1.0495; P=0.124) incidence on Others (non Hispanic) versus White (OR=0.7043; 95% IC 0.4934; 1.0054; P=0.054) and mortality on Asian/pacific Islander versus White (HR=1.0725; 95% IC 0.8253; 1.3939; P=0.60);on Black versus White (HR=1.1992; 95% IC 0.9836; 1.4619; P=0.072); on Hispanic versus White (HR= 1.168; 95% IC 1.0066; 1.3555; P=0.041). Conclusions: This systematic review and meta-analysis indicated more incidence on black and hispanic children and mortality on Hispanic children when compared to white children. Author, year Ethinic group With neuroblastoma Without neuroblastoma Gropus Study Type Age Follow up Urayma, 2006 White, non- Hispanic 254 368 622 Case-Control < 5 years Black, non-Hispanic 37 66 103 Hispanic 168 467 635 Other, non-Hispanic 46 110 156 Stiller, 2000 White 1126 1346 Descriptive retrospective observational study. na Annual South Asian 68 Black 19 Other 133 Sharma, 2022 White 443 561 Retrospective cohort analysis < 45 years nao informa Black 52 45-59 years Asian/Pacific Islander 60 60-79 years Alaskan Native/Native American 0 >= 80 years Other 6 Schraw, 2022 White 287 Case-control < 1 year nao informa Black 36 2 years Hispanic 147 > 3 years Rebecca, 2018 White 1214 1901 Descriptive retrospective observational study. 0-19 years nao informa Black 264 Hispanic 423 Pui, 2012 White (1992-2001) 96 Descriptive retrospective observational study. 0-19 years 10 year Black 521 White (2002-2007) 53 Black 739 Linabery, 2008 White (1975-1979) 208 Retrospective cohort study. 0-19 years 5 years e 10 years Black 25 White (1985-1989) 217 Black 32 White (1995-1999) 231 Black 42 Johnson, 2011 White 1625 Retrospective cohort study. 1-19 years na Black 227 American Indian/ Alaskan Native 11 Asian/Pacific Islander 149 Other 22 Gurney, 1995 White 632 Descriptive ecological retrospective study. 0-15 years na Black 78 Friedrich, 2017 White 1200 Descriptive retrospective observational study. 0-19 years na Hispanic 393 Black 238 Native Hawaiian/Asian Pacific Islander 130 American Indian/Alaska Native; 13 Farouk, 2020 White, Hispanic 190 Descriptive retrospective observational study 0-17 years na White, Non-Hispanic 1490 Black, Hispanic 7 Black, Non-Hispanic 267 Asian/Pacifc Islander, Non-Hispanic 158 Asian/Pacifc Islander, Hispanic 7 Chow,2010 White 806 Case-control < 1 year na Black 65 2 years Hispanic 186 > 3 years Asian 36 Other 1 Campbel, 2023 White 7455 Cohort study 0-19 years 5 year Black 1476 Asian/Pacifc islander 513 American Indian/Alaska Native; 90 Hispanic 1836