Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry

J Jonathan Schulte (Institute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany) E Eric Schwegler (Faculty of Chemistry and Earth Sciences Institute of Organic Chemistry and Macromolecular Chemistry) U Ute A. Hellmich N Nina Morgner (Institute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany)

Article Details

Volume / Issue Vol. 148, Issue 14
Published April 15, 2026
Pages 14813-14823
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (4)

J

Jonathan Schulte

Institute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany

E

Eric Schwegler

Faculty of Chemistry and Earth Sciences Institute of Organic Chemistry and Macromolecular Chemistry

U

Ute A. Hellmich

N

Nina Morgner

Institute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany