Quantification of Binding of Small Molecules to Native Kinases by Flow Cytometry Reveals Divergence from Biochemical Affinities

L Lillian M. Cool J Jogendra Pawar (The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States) S Sonam Sonam S Smita Kumari S Serena Li Zhao X Xiaojun Hu Z Zhihong Lin (The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States) M Meng Wu S Shuiying Hu (The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States) B Blake R. Peterson (The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States)

Article Details

Volume / Issue Vol. 148, Issue 26
Published July 08, 2026
Pages 27613-27625
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (10)

L

Lillian M. Cool

J

Jogendra Pawar

The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States

S

Sonam Sonam

S

Smita Kumari

S

Serena Li Zhao

X

Xiaojun Hu

Z

Zhihong Lin

The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States

M

Meng Wu

S

Shuiying Hu

The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States

B

Blake R. Peterson

The Ohio State University Comprehensive Cancer Center─Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, 460 W. 10th Ave., Columbus, Ohio 43210, United States