PyBOX‐Integrated Chiral Covalent Organic Frameworks

F Fei Li Y Yun‐Long Zhang (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China) H Han‐Hui Wang (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China) J Jing‐Lan Kan (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China) B Bing‐Jian Yao (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China) Y Yu‐Bin Dong (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China)

Abstract

Abstract Heterogeneous catalysts based on chiral covalent organic frameworks (CCOFs) are the new sensation in asymmetric catalysis. The pyridine‐bis(oxazoline) (PyBOX), on the other hand, is a well‐known class of privileged chiral ligands that can be incorporated with various metal ions for diversified homogeneous asymmetric organic transformations. The integration of the PyBOX into the COF platform will undoubtedly lead to a new breed of heterogeneous asymmetric catalysts. Herein, we report the first example of PyBOX‐based CCOF via chiral pool synthesis for scale‐up catalytic asymmetric acetalization and A 3 ‐coupling reaction. This research provides a novel type of sustainable COF‐based heterogeneous catalyst with gratifying functionalities.

Article Details

Volume / Issue Vol. 64, Issue 35
Published August 25, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (6)

F

Fei Li

Y

Yun‐Long Zhang

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China

H

Han‐Hui Wang

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China

J

Jing‐Lan Kan

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China

B

Bing‐Jian Yao

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China

Y

Yu‐Bin Dong

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University Jinan 250014 P.R. China