Pulvinar Subregions Influence Select Cortical Pathways in Humans

Abstract

The pulvinar is a large, multisensory thalamic hub with distinct subregions and widespread cortical connectivity. This widespread connectivity is thought to regulate the flow of information across the cortex, and recent studies have leveraged the pulvinar for neuromodulation. The evolutionary expansion, particularly for the medial pulvinar in humans, highlights the importance to study selective pulvinar influence across the human cortex. We therefore used single-pulse electrical stimulation to causally map the influence of pulvinar on the cortex in 30 patients (14 female) implanted with stereotactic EEG for drug-resistant epilepsy monitoring. In individual subjects, we found that stimulation of the lateral pulvinar influenced striate and extrastriate regions, while ventral–medial pulvinar stimulation preferentially influenced lateral temporal cortices. Across all subjects, the dorsomedial pulvinar stimulation influenced the parietal cortex. Furthermore, these effects were captured by a compact set of large-scale cortical gradients, including outputs along a dorsal–ventral, anterior–posterior, and medial–lateral pulvinar axis. These findings demonstrate that pulvinar subregions influence select cortical networks in humans. These maps of influence may guide further development of pulvinar subregions as distinct neuromodulation targets.