Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation

Oussama M. Wazni; K.R. Julian Chun; Devi G. Nair; Ante Anic; Mattias Duytschaever; Jonathan Chrispin; Anish Amin; Olujimi A. Ajijola; Douglas N. Gibson; Moussa Mansour; Jonathan P. Piccini; Andrea Natale; Auroa Badin; Joaquin Osca; Jonathan Dukes; Karan Bhalla; Ayman Hussein; Todd Senn; Stanislav Weiner; Nitesh Sood; Antonio Dello Russo; Ashish Sadhu; Jason Meyers; Kevin Trulock; Mark T.K. Tam; David B. DeLurgio; Jean Champagne; Saverio Iacopino; Brian Kwan; Elizabeth M. Albrecht; Sheryl McCammon; Ann C. Garlitski; Brad S. Sutton; Kenneth M. Stein; Jason G. Andrade

doi:10.1056/nejmoa2600929

Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation

O Oussama M. Wazni (Cleveland Clinic, Cleveland) K K.R. Julian Chun (Cardioangiologisches Centrum Bethanien, Frankfurt, Germany) D Devi G. Nair (St. Bernards Medical Center and Arrhythmia Research Group, Jonesboro, AR) A Ante Anic (Split University Clinical Hospital, Split, Croatia) M Mattias Duytschaever (St. Jan Hospital, Bruges, Belgium) J Jonathan Chrispin (Johns Hopkins University School of Medicine, Baltimore) A Anish Amin (OhioHealth Heart and Vascular Physicians, Riverside Methodist Hospital, Columbus) O Olujimi A. Ajijola (Ronald Reagan UCLA Medical Center, Los Angeles) D Douglas N. Gibson (Scripps Clinic and Prebys Cardiovascular Institute, San Diego, CA) M Moussa Mansour (Massachusetts General Hospital, Boston) J Jonathan P. Piccini (Duke University, Durham, NC) A Andrea Natale (Texas Cardiac Arrhythmia Research, St. David’s Medical Center, Austin) A Auroa Badin (OhioHealth Heart and Vascular Physicians, Riverside Methodist Hospital, Columbus) J Joaquin Osca (Hospital Universitario La Fe, Valencia, Spain) J Jonathan Dukes (Cardiology Associates Medical Group, Ventura, CA) K Karan Bhalla (Orion Medical, Houston) A Ayman Hussein (Cleveland Clinic, Cleveland) T Todd Senn (Memorial Health University Medical Center, Savannah, GA) S Stanislav Weiner (Christus Trinity Mother Frances Health System, Tyler, TX) N Nitesh Sood (Southcoast Physicians Group, Fall River, MA) A Antonio Dello Russo (Biomedical Science and Public Health Department, Marche University Hospital, Ancona, Italy) A Ashish Sadhu (Phoenix Cardiovascular Research Group, Phoenix, AZ) J Jason Meyers (MercyOne Iowa Heart Center, West Des Moines) K Kevin Trulock (Community Heart and Vascular Hospital, Indianapolis) M Mark T.K. Tam (Chinese University of Hong Kong, Hong Kong) D David B. DeLurgio (Emory University School of Medicine, Atlanta) J Jean Champagne (Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, Canada) S Saverio Iacopino (Arrhythmia Department, Maria Cecilia Hospital, GVM Care and Research, Cotignola, Italy) B Brian Kwan (Boston Scientific, St. Paul, MN) E Elizabeth M. Albrecht (Boston Scientific, St. Paul, MN) S Sheryl McCammon (Boston Scientific, St. Paul, MN) A Ann C. Garlitski (Boston Scientific, St. Paul, MN) B Brad S. Sutton (Boston Scientific, St. Paul, MN) K Kenneth M. Stein (Boston Scientific, St. Paul, MN) J Jason G. Andrade (Vancouver General Hospital, Vancouver, BC, Canada)

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Article Details

Journal New England Journal of Medicine

Volume / Issue Vol. 394, Issue 24

Published June 25, 2026

Pages 2407-2418

DOI 10.1056/nejmoa2600929

ISSN 0028-4793

Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (35)

O

Oussama M. Wazni

Cleveland Clinic, Cleveland

K

K.R. Julian Chun

Cardioangiologisches Centrum Bethanien, Frankfurt, Germany

D

Devi G. Nair

St. Bernards Medical Center and Arrhythmia Research Group, Jonesboro, AR

A

Ante Anic

Split University Clinical Hospital, Split, Croatia

M

Mattias Duytschaever

St. Jan Hospital, Bruges, Belgium

J

Jonathan Chrispin

Johns Hopkins University School of Medicine, Baltimore

A

Anish Amin

OhioHealth Heart and Vascular Physicians, Riverside Methodist Hospital, Columbus

O

Olujimi A. Ajijola

Ronald Reagan UCLA Medical Center, Los Angeles

D

Douglas N. Gibson

Scripps Clinic and Prebys Cardiovascular Institute, San Diego, CA

M

Moussa Mansour

Massachusetts General Hospital, Boston

J

Jonathan P. Piccini

Duke University, Durham, NC

A

Andrea Natale

Texas Cardiac Arrhythmia Research, St. David’s Medical Center, Austin

A

Auroa Badin

OhioHealth Heart and Vascular Physicians, Riverside Methodist Hospital, Columbus

J

Joaquin Osca

Hospital Universitario La Fe, Valencia, Spain

J

Jonathan Dukes

Cardiology Associates Medical Group, Ventura, CA

K

Karan Bhalla

Orion Medical, Houston

A

Ayman Hussein

Cleveland Clinic, Cleveland

T

Todd Senn

Memorial Health University Medical Center, Savannah, GA

S

Stanislav Weiner

Christus Trinity Mother Frances Health System, Tyler, TX

N

Nitesh Sood

Southcoast Physicians Group, Fall River, MA

A

Antonio Dello Russo

Biomedical Science and Public Health Department, Marche University Hospital, Ancona, Italy

A

Ashish Sadhu

Phoenix Cardiovascular Research Group, Phoenix, AZ

J

Jason Meyers

MercyOne Iowa Heart Center, West Des Moines

K

Kevin Trulock

Community Heart and Vascular Hospital, Indianapolis

M

Mark T.K. Tam

Chinese University of Hong Kong, Hong Kong

D

David B. DeLurgio

Emory University School of Medicine, Atlanta

J

Jean Champagne

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, Canada

S

Saverio Iacopino

Arrhythmia Department, Maria Cecilia Hospital, GVM Care and Research, Cotignola, Italy

B

Brian Kwan