Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity
Abstract
ABSTRACT The precise control of assembly dimensionality and macroscopic structural parameters remains a fundamental challenge in molecular self‐assembly. Here, we introduce a programmable strategy to govern the 1D‐to‐2D dimensional transition and structural width of DNA brick crystals by engineering their connecting interfaces. Using the number of interface connecting strands ( N x ) as a quantitative design parameter, we discover a sharp dimensional threshold that is preserved across both honeycomb and square lattices. At N x ≤ 8, the assembly is strictly confined to one‐dimensional nanoribbons; whereas at N x ≥ 12, lateral coupling activates extended two‐dimensional arrays whose structural width increases monotonically with N x . Thermal and thermodynamic analyses reveal that this sharp threshold behavior is lattice‐independent and originates from the size‐dependent thermal stability of the laterally connected domains. Our work establishes interfacial connectivity as a predictive handle for the on‐demand engineering of self‐assembled nanostructures with programmable dimensionality and prescribed widths.
Article Details
Authors (10)
Xin Huang
Yue Wang
Wenhe Ma
State Key Laboratory of Synergistic Chem-Bio Synthesis, State Key Laboratory of Micro-Nano Engineering Science, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine
Yunxiao Lin
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine
Bochen Li
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine
Jiang Li
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica
Lihua Wang
Chunhai Fan
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine
Sisi Jia
Zhangjiang Laboratory
Xiaoguo Liu
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine