Pretargeted Multimodal Tumor Imaging by Enzymatic Self-Immobilization Labeling and Bioorthogonal Reaction

Yinxing Miao; Yuqi Wang; Yefeng Chen; Zheng Huang; Chunmei Lu; Yili Liu; Fangfang Chen; Xidan Wen; Junya Zhang; Shiliang Zhu; Pengke Zhao; Yunhan Chen; Tian Tian; Yan Zhang; Hexin Xie; Jianguo Lin; Deju Ye

doi:10.1021/jacs.4c15896

Journal of the American Chemical Society

Pretargeted Multimodal Tumor Imaging by Enzymatic Self-Immobilization Labeling and Bioorthogonal Reaction

Y Yinxing Miao (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering) Y Yuqi Wang Y Yefeng Chen (State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China) Z Zheng Huang (College of Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, College of Energy, School of Life Sciences, College of Physical Science and Technology, and Discipline of Intelligent Instrument and Equipment) C Chunmei Lu (State Key Laboratory of Analytical Chemistry for Life Science, Department of General Surgery & Pathology, Nanjing Drum Tower Hospital, School of Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC)) Y Yili Liu (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Road, Nanjing 210023, China) F Fangfang Chen X Xidan Wen (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Road, Nanjing 210023, China) J Junya Zhang (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Road, Nanjing 210023, China) S Shiliang Zhu (NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China) P Pengke Zhao (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Road, Nanjing 210023, China) Y Yunhan Chen (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Road, Nanjing 210023, China) T Tian Tian Y Yan Zhang H Hexin Xie (State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Pharmacy) J Jianguo Lin (NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China) D Deju Ye (State Key Laboratory of Analytical Chemistry for Life Science, Department of General Surgery & Pathology, Nanjing Drum Tower Hospital, School of Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC))

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Article Details

Journal Journal of the American Chemical Society

Volume / Issue Vol. 147, Issue 3

Published January 22, 2025

Pages 2809-2821

DOI 10.1021/jacs.4c15896

ISSN 0002-7863

Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (17)

Y

Yinxing Miao

State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering

Y

Yuqi Wang

Y

Yefeng Chen

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Z

Zheng Huang

College of Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, College of Energy, School of Life Sciences, College of Physical Science and Technology, and Discipline of Intelligent Instrument and Equipment

C

Chunmei Lu

State Key Laboratory of Analytical Chemistry for Life Science, Department of General Surgery & Pathology, Nanjing Drum Tower Hospital, School of Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC)

Y

Yili Liu